Nolva-Jet
Tamoxifen Citrate
Strength
20 mg/Tablet
Dosage
20 mg per day
Packaging
100 Tablet
DESCRIPTION
Tamoxifen Citrate is the citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependent manner, inhibiting signal transduction and producing an anti-proliferative effect in tumours such as malignant glioma and other cancers. It also helps to retain their muscle gains and prevent potential problems with gynecomastia.
The chemical name for Tamoxifen Citrate is (Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethylamine citrate (1:1) and its structural formula is